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Publications Nicole Linka



Wrobel T, Brilhaus D, Stefanski A, Stühler K, Weber APM, Linka N. 2023. Mapping the castor bean endosperm proteome revealed a metabolic interaction between plastid, mitochondria, and peroxisomes to optimize seedling growth. Frontiers in Plant Science; DOI 10.3389/fpls.2023.1182105

Perdosa AG, Reglinski K, Lismont C, Kors S, Costelo J, Rodrigues TA, Marques M, Linka N, Argyriou C. weinhofer I, Kocherlakota S, Riccio V, Ferreira V, Di Cara F, Francisco T, Azevedo JE Ribeiro D. 2023. Peroxisomes: novel findings and future directions. Histochemistry and Cell Biology. https://doi.org/10.1007/s00418-023-02201-9

Huang W, Krishan A, Plett A, Meagher M, Linka N, Wang Y, Ren B, Findinier J, Redekop P, Fakhimi N, Kim  RG, Karns DA, Boyle N, Posewitz MC, Grossmann AR. 2023. Chlamydomonas mutats lacking chloroplast TRIOSE PHOSPHATE TREANSPORTER3 are metabolically compromised and light-sensitive. The Plant Cell.https://doi.org/10.1093/plcell/koad095


Feitosa-Araujo F, da Fonseca-Pereira P, Pena MM, Lana-Costa J, Coelho DG, de Oliveira Silva FM, Medeiros DB, Linka N, Araujo WL, Weber APM, Fernie AR, Nunes-Nesi A. 2022. Mitochondrial and peroxisomal NAD+ uptake are important for improved photosynthesis and seed yield under elevated CO2 concentrations. The Plant Journal 111, 713-730. https://doi.org/10.1111/tpj.15846

van Roermund CWT,  IJlst L, Linka N, Wanders RJA, Waterham. 2022. Peroxisomal ATP Uptake Is Provided by Two Adenine Nucleotide Transporters and the ABCD Transporters. Frontiers in Cell and Developmental Biology 9, article 788921.


Kuhnert F, Schlüter U, Linka N, Eisenhut M. 2021. Transport proteins enabling plant photorespiratory metabolism. Plants, 10(5):880. doi: 10.3390/plants10050880.


Brito DS, Agrimi G, Charton L, Brilhaus D, Bitetto MG, Lana-Costa J, Messina E, Nascimento CP, Feitosa-Araújo E, Pires MV, Pérez-Díaz JL, Obata T, Porcelli V, Palmieri L, Araújo WL, Weber APM, Linka N, Fernie AR, Palmieri F, Nunes-Nesi A. (2020) Biochemical and functional characterization of a mitochondrial citrate carrier in Arabidopsis thaliana. Biochem J. 2020 May 15;477(9):1759-1777. doi: 10.1042/BCJ20190785.

Plett A, Charton L, Linka N. (2020) Peroxisomal Cofactor Transport. Biomolecules. 10(8): 1174. doi: 10.3390/biom10081174

Schmitz J, Hüdig M, Meier D, Linka N, Maurino VG. (2020) The genome of Ricinus communis encodes a single glycolate oxidase with different functions in photosynthetic and heterotrophic organs. Planta, 252(6):100. doi.org/10.1007/s00425-020-03504-0

Baune MC, Lansing H, Fischer K, Meyer T, Charton L, Linka N, von Schaewen A. (2020) The Arabidopsis Plastidial Glucose-6-phosphate Transporter GPT1 is Dually Targeted to Peroxisomes via the Endoplasmic Reticulum. Plant Cell. pii: tpc.00959.2019. doi: 10.1105/tpc.19.00959.

de Souza Chaves I, Feitosa-Araújo E, Florian A, Medeiros DB, da Fonseca-Pereira P, Charton L, Heyneke E, Apfata JAC, Pires MV, Mettler-Altmann T, Araújo WL, Neuhaus HE, Palmieri F, Obata T, Weber APM, Linka N, Fernie AR, Nunes-Nesi A. (2020) The mitochondrial NAD+ transporter (NDT1) plays important roles in cellular NAD+ homeostasis in Arabidopsis thaliana. Plant J 100(3): 487-504. doi: 10.1111/tpj.14452.

Kim YI, Nam IK, Lee DK, Bhandari S, Charton L, Kwak S, Lim JY, Hong K, Kim SJ, Lee JN, Kwon SW, So HS, Linka N, Park R, Choe SK. (2020) Slc25a17 acts as a peroxisomal coenzyme A transporter and regulates multiorgan development in zebrafish. J Cell Physiol 235(1): 151-165. doi: 10.1002/jcp.28954.

Feitosa-Araujo E, Chaves IS, Florian A, da Fonseca-Pereira P, Apfata JAC, Heyneke E, Medeiros DB, Pires MV, Mettler-Altmann T, Neuhaus HE, Palmieri F, Araújo WL, Obata T, Weber APM, Linka N, Fernie AR, Nunes-Nesi A. (2020) Down-regulation of a Mitochondrial NAD+ Transporter (NDT2) Alters Seed Production and Germination in Arabidopsis. Plant Cell Physiol. pii: pcaa017. doi: 10.1093/pcp/pcaa017.


Shanmugarajah K, Linka N, Gräfe K, Smits SHJ, Weber APM, Zeier J, Schmitt L. (2019) ABCG1 contributes to suberin formation in Arabidopsis thaliana roots. Sci Rep 9(1): 11381. doi: 10.1038/s41598-019-47916-9.

Costello JL, Zalckvar E, Kemp S, di Cara F, Kim PK, Linka N, van der Klei IJ. (2019) Peroxisomes: new insights into protein sorting, dynamics, quality control, signalling and roles in health and disease. Histochem Cell Biol 151(4): 283-289. doi: 10.1007/s00418-019-01780-w.

Charton L, Plett A, Linka N. (2019) Plant peroxisomal solute transporter proteins. J Integr Plant Biol 61(7): 817-835. doi: 10.1111/jipb.12790.


Delporte M, Bernard G, Legrand G, Hielscher B, Lanoue A, Molinié R, Rambaud C, Mathiron D, Besseau S, Linka N, Hilbert JL, Gagneul D. (2018) A BAHD neofunctionalization promotes tetrahydroxycinnamoyl spermine accumulation in the pollen coat of the Asteraceae family. J Exp Bot 69(22): 5355-5371. doi: 10.1093/jxb/ery320.


Hielscher B, Charton L, Mettler-Altmann T, Linka N. (2017) Analysis of Peroxisomal β-Oxidation During Storage Oil Mobilization in Arabidopsis thaliana Seedlings. Methods Mol Biol 1595: 291-304. doi: 10.1007/978-1-4939-6937-1_27.


van Roermund CW, Schroers MG, Wiese J, Facchinelli F, Kurz S, Wilkinson S, Charton L, Wanders RJ, Waterham HR, Weber AP, Link N. (2016) The Peroxisomal NAD Carrier from Arabidopsis Imports NAD in Exchange with AMP. Plant Physiol 171(3): 2127-39. doi: 10.1104/pp.16.00540.


Pade N, Linka N, Ruth W, Weber AP, Hagemann M. (2015) Floridoside and isofloridoside are synthesized by trehalose 6-phosphate synthase-like enzymes in the red alga Galdieria sulphuraria. New Phytol 205(3): 1227-38. doi: 10.1111/nph.13108.


Kessel-Vigelius SK, Wiese J, Schroers MG, Wrobel TJ, Hahn F, Linka N. (2013) An engineered plant peroxisome and its application in biotechnology. Plant Sci 210: 232-40. doi: 10.1016/j.plantsci.2013.06.005.

Linka N, Theodoulou FL. (2013) Metabolite transporters of the plant peroxisomal membrane: known and unknown. Subcell Biochem 69: 169-94. doi: 10.1007/978-94-007-6889-5_10.

Theodoulou FL, Bernhardt K, Linka N, Baker A. (2013) Peroxisome membrane proteins: multiple trafficking routes and multiple functions? Biochem J 451(3): 345-52. doi: 10.1042/BJ20130078.

Linka N, Theodoulou F. (2013) Metabolite transporters of the plant peroxisomal membrane - known and unknown. In “Peroxisomes as a Cellular Source of Different Signaling Molecules”, Subcellular Biochemistry 69, 169-194, Editor Del Rio, L.A, Springer, DOI:  doi: 10.1007/978-94-007-6889-5_10.


Hu J, Baker A, Bartel B, Linka N, Mullen RT, Reumann S, Zolman BK. (2012) Plant peroxisomes: biogenesis and function. Plant Cell 24(6): 2279-303. doi: 10.1105/tpc.112.096586.

Linka N, Esser C. (2012) Transport proteins regulate the flux of metabolites and cofactors across the membrane of plant peroxisomes. Front Plant Sci 3: 3. doi: 10.3389/fpls.2012.00003. eCollection 2012.

Haferkamp I, Linka N. (2012) Functional expression and characterisation of membrane transport proteins. Plant Biol (Stuttg) 14(5):675-90. doi: 10.1111/j.1438-8677.2012.00591.x.

Bernhardt K, Wilkinson S, Weber AP, Linka N. (2012) A peroxisomal carrier delivers NAD⁺ and contributes to optimal fatty acid degradation during storage oil mobilization. Plant J 69(1): 1-13. doi: 10.1111/j.1365-313X.2011.04775.x.


Weber AP, Linka N. (2011) Connecting the plastid: transporters of the plastid envelope and their role in linking plastidial with cytosolic metabolism. Annu Rev Plant Biol 62: 53-77. doi: 10.1146/annurev-arplant-042110-103903.


Linka N, Weber AP. (2010) Intracellular metabolite transporters in plants. Mol Plant 3(1): 21-53. doi: 10.1093/mp/ssp108.


Reumann S, Quan S, Aung K, Yang P, Manandhar-Shrestha K, Holbrook D, Linka N, Switzenberg R, Wilkerson CG, Weber AP, Olsen LJ, Hu J. (2009) In-depth proteome analysis of Arabidopsis leaf peroxisomes combined with in vivo subcellular targeting verification indicates novel metabolic and regulatory functions of peroxisomes. Plant Physiol 150(1): 125-43. doi: 10.1104/pp.109.137703.


Linka N, Theodoulou FL, Haslam RP, Linka M, Napier JA, Neuhaus HE, Weber AP. (2008) Peroxisomal ATP import is essential for seedling development in Arabidopsis thaliana. Plant Cell 20(12): 3241-57. doi: 10.1105/tpc.108.062042.


Nozawa A, Nanamiya H, Miyata T, Linka N, Endo Y, Weber AP, Tozawa Y. (2007) A cell-free translation and proteoliposome reconstitution system for functional analysis of plant solute transporters. Plant Cell Physiol 48(12): 1815-20. doi: 10.1093/pcp/pcm150.


Bouvier F, Linka N, Isner JC, Mutterer J, Weber AP, Camara B. (2006) Arabidopsis SAMT1 defines a plastid transporter regulating plastid biogenesis and plant development. Plant Cell 18(11): 3088-105. doi: 10.1105/tpc.105.040741.


Weber AP, Oesterhelt C, Gross W, Bräutigam A, Imboden LA, Krassovskaya I, Linka N, Truchina J, Schneidereit J, Voll H, Voll LM, Zimmermann M, Jamai A, Riekhof WR, Yu B, Garavito RM, Benning C. (2004) EST-analysis of the thermo-acidophilic red microalga Galdieria sulphuraria reveals potential for lipid A biosynthesis and unveils the pathway of carbon export from rhodoplasts. Plant Mol Biol 55(1): 17-32. doi: 10.1007/s11103-004-0376-y.

Haferkamp I, Schmitz-Esser S, Linka N, Urbany C, Collingro A, Wagner M, Horn M, Neuhaus HE. (2004) A candidate NAD+ transporter in an intracellular bacterial symbiont related to Chlamydiae. Nature 432(7017): 622-5. doi: 10.1038/nature03131.

Reiser J, Linka N, Lemke L, Jeblick W, Neuhaus HE. (2004) Molecular physiological analysis of the two plastidic ATP/ADP transporters from Arabidopsis. Plant Physiol 136(3): 3524-36. doi: 10.1104/pp.104.049502.

Daugherty RM, Linka N, Audia JP, Urbany C, Neuhaus HE, Winkler HH. (2004) The nucleotide transporter of Caedibacter caryophilus exhibits an extended substrate spectrum compared to the analogous ATP/ADP translocase of Rickettsia prowazekii. J Bacteriol 186(10):3262-5. doi: 10.1128/jb.186.10.3262-3265.2004.

Schmitz-Esser S, Linka N, Collingro A, Beier CL, Neuhaus HE, Wagner M, Horn M. (2004) ATP/ADP translocases: a common feature of obligate intracellular amoebal symbionts related to Chlamydiae and Rickettsiae. J Bacteriol 186(3): 683-91. doi: 10.1128/jb.186.3.683-691.2004.


Emmerlich V, Linka N, Reinhold T, Hurth MA, Traub M, Martinoia E, Neuhaus HE. (2003) The plant homolog to the human sodium/dicarboxylic cotransporter is the vacuolar malate carrier. Proc Natl Acad Sci U S A 100(19): 11122-6. doi: 10.1073/pnas.1832002100.

Linka N, Hurka H, Lang BF, Burger G, Winkler HH, Stamme C, Urbany C, Seil I, Kusch J, Neuhaus HE. (2003) Phylogenetic relationships of non-mitochondrial nucleotide transport proteins in bacteria and eukaryotes. Gene 306: 27-35. doi: 10.1016/s0378-1119(03)00429-3

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